The Patient-Centered Outcomes Research Institute (PCORI) seeks to fund high-quality patient-centered comparative clinical effectiveness research (CER) projects that focus on substance use/misuse and substance use disorders.
Those interested in applying can register to attend the Applicant Town Hall on May 16, 2024, at noon (ET), where researchers and stakeholders will learn more about this funding announcement. Register here.
PCORI is particularly interested in applications focusing on evidence-based strategies to advance equity in the prevention and treatment of substance use disorders, evidenced-based interventions for overdose prevention and strategies to reduce nicotine and tobacco use in disproportionally affected populations, but applications are not limited to these areas.
Applications may propose comparative clinical effectiveness studies of prevention, harm reduction, treatment and recovery approaches for substance use/misuse and substance use disorders at the individual, community or systems level to improve patient-centered substance-use-related outcomes.
Applications proposing novel interventions and/or aiming to develop new technologies (such as mobile apps) or decision support tools/aids will be considered nonresponsive. Adaptations of efficacious interventions used in the general population may be responsive, but the level of adaptation must be clearly described and justified a priori.
PCORI is particularly interested in submissions that address the following Special Areas of Emphasis:
- Evidence-Based Strategies to Advance Equity in the Prevention and Treatment of Substance Use Disorders: Historically underserved and under-resourced populations experience significant disparities in outcomes and inequities in access to the continuum of care for substance use/misuse and substance use disorders. PCORI is interested in evidence-based approaches that advance health equity, with a strong recommendation to include individuals with lived experience contributing to the design of the study. Studies could include community-centered recovery models, trauma-informed care and peer support interventions.
- Evidence Based Interventions for Overdose Prevention: Overdose remains a deadly issue in the United States, with over 75 percent of overdose deaths involving opioids and nearly half involving multiple drugs. PCORI is interested in patient-centered CER of system-, community- and individual-level interventions to reduce overdose-related negative health outcomes and deaths, particularly for historically marginalized and under-resourced populations. Examples of studies may include harm reduction strategies, multi-level interventions and approaches that increase linkage to medications for opioid use disorder (MOUD).
- Strategies to Reduce Nicotine and Tobacco Use in Disproportionally Affected Populations: Despite quit attempts and longer-term cessation increasing over the past two decades, considerable disparities remain in the prevalence of nicotine and tobacco use across races and ethnicities, as well as the prevalence of key indicators of smoking cessation. PCORI is interested in funding patient-centered CER assessing different forms, doses, durations and delivery of treatments, particularly when focused on disparities and health equity. Studies may include school-based initiatives, digital therapeutics and pharmacotherapy approaches.
Those interested in applying can also email [email protected] with questions about this funding opportunity. Feel free to share this information with anyone who may be interested.
